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2023

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Fakim H, Vande Velde C. (2023). The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis. Semin Cell Dev Biol. 2023 May 31:S1084-9521(23)00115-5. doi: 10.1016/j.semcdb.2023.05.006. Online ahead of print. PMID: 37268555

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Dubinski A, Gagné M, Peyrard S, Gordon D, Talbot K, Vande Velde C. (2023). Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice. Hum Mol Genet. 2023 Jan 6;32(2):319-332. doi: 10.1093/hmg/ddac206. PMID: 35994036

Picher-Martel V, Magnussen C, Blais M, Bubela T, Das S, Dionne A, Evans AC, Genge A, Greiner R, Iturria-Medina Y, Johnston W, Jones K, Kaneb H, Karamchandani J, Moradipoor S, Robertson J, Rogaeva E, Taylor DM, Vande Velde C, Yunusova Y, Zinman L, Kalra S, Dupré N. CAPTURE ALS: the comprehensive analysis platform to understand, remedy and eliminate ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Feb;24(1-2):33-39. doi: 10.1080/21678421.2022.2041668. PMID: 35195049

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2022

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Sidibé H, Vande Velde C. (2022). Collective Learnings of Studies of Stress Granule Assembly and Composition. Methods Mol Biol. 2022;2428:199-228. doi: 10.1007/978-1-0716-1975-9_13. PMID: 35171482

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Garg P, Semmler S, Baudouin C, Vande Velde C, Plotkin SS. Misfolding-Associated Exposure of Natively Buried Residues in Mutant SOD1 Facilitates Binding to TRAF6. J Mol Biol. 2022 Aug 30;434(16):167697. doi: 10.1016/j.jmb.2022.167697. PMID 35753527

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2021

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Gagné M, Deshaies JE, Sidibé H, Benchaar Y, Arbour D, Dubinski A, Litt G, Peyrard S, Robitaille R, Sephton CF, Vande Velde C. (2021). hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated. Front Neurosci. 2021 Sep 24;15:724307. doi: 10.3389/fnins.2021.724307. eCollection 2021. PMID 34630013

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Dubinski A, Vande Velde C. (2021). Altered stress granule disassembly: links to neurodegenerative disease? Trends Neurosci 2021 Aug 21:S0166-2236(21)00160-0. doi: 10.1016/j.tins.2021.08.001. Online ahead of print. PMID: 34429216

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Sidibé H, Khalfallah Y, Xiao S, Gómez NB, Fakim H, Tank EMH, Tomasso GD, Bareke E, Aulas A, McKeever PM, Melamed Z, Destroimaisons L, Deshaies JE, Zinman L, Parker JA, Legault P, Tétreault M, Barmada SJ, Robertson J, Vande Velde C. (2021). TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia. Brain 144:3461-3476.  PMID: 34115105

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Vu L*, Ghosh A*, Tran C, Tebung WA, Sidibé H, Garcia-Mansfield K, David-Dirgo V, Sharma R, Pirrotte P, Bowser R, Vande Velde C. (2021). Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions. J Proteome Res 20(6):3165-3178. PMID: 33939924

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Sidibé H, Dubinski A, Vande Velde C. (2021). The multi-functional RNA-binding protein G3BP1 and its potential implication in neurodegenerative disease. J Neurochem 157(4):944-962. PMID: 33349931 

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2020

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Martineau E, Di Polo A, Vande Velde C, Robitaille R. (2020). Sex-specific differences in motor-unit remodeling in a mouse model of ALS. eNeuro 7(1).  PMID: 32033983

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Semmler S, Gagné M, Garg P, Pickles S, Baudouin C, Hamon-Keromen E, Destroismaisons L, Khalfallah Y, Chaineau M, Caron E, Bayne AN, Trempe JF, Cashman NR, Star AT, Haqqani AS, Durcan T, Meiering EM, Robertson J, Grandvaux N, Plotkin SS, McBride HM, Vande Velde C. (2020). The E3 ubiquitin ligase TRAF6 is a novel interacting protein of amyotrophic lateral sclerosis-linked misfolded SOD1. J Biol Chem 295:3803-3825.  PMID: 30364932

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2019

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Sidibé H, Vande Velde C. RNA granules and their role in neurodegenerative disease development and progression. (2019) Invited book chapter. Nature Springer. Editors: Oeffinger M and Zenklusen D. Adv Exp Med Biol 1203: 195-245. PMID: 31811636

 

2018

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Martineau E, Di Polo A, Vande Velde C, Robitaille R.  Dynamic neuromuscular remodelling precedes motor-unit loss in a model of ALS. Elife 7. pii: e41973. PMID: 30320556

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Tétreault M, Deshaies JE, Semmler S, Sidibé H, Shkreta L, Volkening K, Soreq H, Strong MJ, Chabot B, Vande Velde C. 

Reply: TDP-43 mutations increase HNRNP A1-7B through gain of splicing function. (2018) Brain 141(12):e84. PMID 30364932

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Khalfallah Y, Kuta R, Grasmuck C, Prat A, Durham HD, Vande Velde C. (2018). TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types. Sci Reports 8:7551. PMID: 29765078

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Deshaies J-E, Shkreta L, Moszczynski AJ, Sidibé H, Semmler S, Fouillen A, Bennett E, Bekenstein U, Destroismaisons L, Toutant J, Delmotte Q, Volkening K, Stabile S, Aulas A, Khalfallah Y, Soreq H, Nanci A, Strong MJ, Chabot B, Vande Velde C. (2018). TDP-43 regulates hnRNP A1 alternative splicing to generate an aggregation prone variant in amyotrophic lateral sclerosis. Brain 141:1320-1333. PMID: 29562314

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2017

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Chiasseu M, Alarcon-Martinez L, Dotigny F, Belforte N, Destroismaisons L, Vande Velde C, Panayi F, Louis C, Di Polo A. (2017). Tau accumulation in the retina of a murine model of Alzheimer’s disease precedes brain pathology and promotes neuronal dysfunction. Mol Neurodegener 12:58. PMID: 28774322.

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Arbour D, Vande Velde C, Robitaille R. (2017). New perspectives on the neuromuscular junction in ALS: The role of glial cells. J Physiology 595:647-661. PMID: 27633977

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2016

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Chiasseu M, Cueva Vargas J, Destroismaisons L, Vande Velde C, Leclerc N, Di Polo A. Tau accumulation in the somato-dendritic compartment of retinal ganglion cells plays a critical role in glaucomatous neurodegeneration. J Neuroscience 36:5785-5798.  PMID: 27225768   (cover)

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Pickles S, Semmler S, Broom HR, Destroismaisons L, Legroux L, Arbour N, Cashman NR, Meiering E, Vande Velde C. ALS-linked misfolded SOD1 species have divergent impacts on mitochondria. Acta Neuropathol Comm 4:43. PMID: 27121871

 

2015

 

Aulas A, Vande Velde C.  Alterations in stress granule dynamics driven by TDP-43 and FUS: A link to pathological inclusions in ALS? Front Cell Neurosci 9:423.  PMID: 26557057

 

Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C.  G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.   J Cell Biol. 2015 Apr 13;209(1):73-84. doi: 10.1083/jcb.201408092. Epub 2015 Apr 6.  PMID: 25847539

 

Capo-Chichi JM, Boissel S, Brustein E, Pickles S, Fallet-Bianco C, Nassif C, Patry L, Dobrzeniecka S, Liao M, Labuda D, Samuels ME, Hamdan FF, Vande Velde C, Rouleau GA, Drapeau P, Michaud JL.  Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria. J Med Genet. 2015 May;52(5):303-11. doi: 10.1136/jmedgenet-2014-102952. Epub 2015 Feb 3.  PMID: 25650066

 

 

2014

 

Pickles S, Arbour N, Vande Velde C.  Immunodetection of outer membrane proteins by flow cytometry of isolated mitochondria.  J Vis Exp. 2014 Sep 18;(91):51887. doi: 10.3791/51887.  PMID: 25285411

 

 

2013

 

Pickles S, Cadieux-Dion M, Alvarez JI, Lécuyer MA, Peyrard SL, Destroismaisons L, St-Onge L, Terouz S, Cossette P, Prat A, Vande Velde C.  Endo-MitoEGFP mice: a novel transgenic mouse with fluorescently marked mitochondria in microvascular endothelial cells. PLoS One. 2013 Sep 3;8(9):e74603. doi: 10.1371/journal.pone.0074603. eCollection 2013.  PMID: 24019971

 

Pickles S, Destroismaisons L, Peyrard SL, Cadot S, Rouleau GA, Brown RH Jr, Julien JP, Arbour N, Vande Velde C.  Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Hum Mol Genet. 2013 Oct 1;22(19):3947-59. doi: 10.1093/hmg/ddt249. Epub 2013 Jun 4. PMID: 23736301

 

 

2012

 

Aulas A, Stabile S, Vande Velde C. Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Mol Neurodegener. 2012 Oct 24;7:54. doi: 10.1186/1750-1326-7-54.  PMID: 23092511

 

Bannwarth S, Figueroa A, Fragaki K, Destroismaisons L, Lacas-Gervais S, Lespinasse F, Vandenbos F, Pradelli LA, Ricci JE, Rötig A, Michiels JF, Vande Velde C, Paquis-Flucklinger V. The human MSH5 (MutSHomolog 5) protein localizes to mitochondria and protects the mitochondrial genome from oxidative damage. Mitochondrion. 2012 Nov;12(6):654-65. doi: 10.1016/j.mito.2012.07.111. Epub 2012 Aug 11.  PMID: 22917773

 

Tauffenberger A, Vaccaro A, Aulas A, Vande Velde C, Parker JA. Glucose delays age-dependent proteotoxicity. Aging Cell. 2012 Oct;11(5):856-66. doi: 10.1111/j.1474-9726.2012.00855.x. Epub 2012 Aug 1. PMID: 22734670

 

Pickles S, Vande Velde C. Misfolded SOD1 and ALS: zeroing in on mitochondria. Amyotroph Lateral Scler. 2012 Jun;13(4):333-40. doi: 10.3109/17482968.2012.648645. Epub 2012 Apr 3. Review. PMID: 22471903

 

 

2011

 

Vande Velde C, Dion PA, Rouleau GA. Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms. F1000 Biol Rep. 2011;3:18. doi: 10.3410/B3-18. Epub 2011 Sep 1.  PMID: 21941597

 

McDonald KK, Aulas A, Destroismaisons L, Pickles S, Beleac E, Camu W, Rouleau GA, Vande Velde C. TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Hum Mol Genet. 2011 Apr 1;20(7):1400-10. doi: 10.1093/hmg/ddr021. Epub 2011 Jan 21. PMID: 21257637

 

 

2010

 

Li Q*, Vande Velde C*, Israelson A, Xie J, Bailey AO, Dong MQ, Chun SJ, Roy T, Winer L, Yates JR, Capaldi RA, Cleveland DW, Miller TM. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21146-51. doi: 10.1073/pnas.1014862107. Epub 2010 Nov 15.  PMID: 21078990  (*co-first)

 

Soucy-Faulkner A, Mukawera E, Fink K, Martel A, Jouan L, Nzengue Y, Lamarre D, Vande Velde C, Grandvaux N. Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression. PLoS Pathog. 2010 Jun 3;6(6):e1000930. doi: 10.1371/journal.ppat.1000930. PMID: 20532218

 

Kabashi E, Lin L, Tradewell ML, Dion PA, Bercier V, Bourgouin P, Rochefort D, Bel Hadj S, Durham HD, Vande Velde C, Rouleau GA, Drapeau P. Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo. Hum Mol Genet. 2010 Feb 15;19(4):671-83. doi: 10.1093/hmg/ddp534. Epub 2009 Dec 3. PMID: 19959528

 

 

2008

 

Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Vande Velde C, Bouchard JP, Lacomblez L, Pochigaeva K, Salachas F, Pradat PF, Camu W, Meininger V, Dupre N, Rouleau GA. TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat Genet. 2008 May;40(5):572-4. doi: 10.1038/ng.132. Epub 2008 Mar 30.  PMID: 18372902

 

Vande Velde C, Miller TM, Cashman NR, Cleveland DW. Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):4022-7. doi: 10.1073/pnas.0712209105. Epub 2008 Feb 22. PMID: 18296640

 

Detmer SA, Vande Velde C, Cleveland DW, Chan DC. Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet. 2008 Feb 1;17(3):367-75. Epub 2007 Oct 24. PMID: 17959936